The Autoimmune Registry
Antisynthetase syndrome Graphs for this disease are generated based on data from the Autoimmune Registry Inc.
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  • Names
    • Antisynthetase syndrome
    • Anti-Jo1 syndrome

    Category: Systemic
    Prevalence From 9,999 to 13,332 cases in the US (Cojocaru 2016). Female/Male ratio: 15.0x.
    Age of Onset Onset typically occurs between ages 43 and 60.
    Description Antisynthetase syndrome is sometimes an autoimmune form of myositis in which antibodies destroy tRNA synthetase, an enzyme that is essential for the creation of important proteins used throughout the body. When that enzyme is destroyed, proteins that the body needs are not produced, and most noteably, proteins used to power the muscles. The result is muscle weakness, but since there are many proteins affected by the loss of tRNA synthetase, it can also impact the lungs and other parts of the body.

    The trigger for antisynthetase syndrome is unknown, but it may be associated with viral infection. Patients with antisynthetase syndrome commonly experience muscle inflammation, lung disease, and joint inflammation. This condition is seen twice as often in women than in men and typically occurs in middle age. This is a chronic disease with no cure, and disease severity and prognosis varies by individual. Patients who only experience muscle symptoms can manage the condition well with treatment. However, prognosis is poor for patients who develop progressive interstitial lung disease.

    Evidence of autoimmunity: Antibody
    Patient Groups
    Bloggers
      Symptoms
      Resources Link to Clinical Trials
      Link to PubMed
      References Link to Cleveland Clinic
      Link to Healthline
      Profile by: Eli Lind
    • Profile updated September 2024
    • Charts generated Nov 16, 2024 at 09:55 AM ET
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      Antisynthetase syndrome sex breakdown


      Antisynthetase syndrome age breakdown

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      Graphs for this disease are generated based on data from the Autoimmune Registry Inc.

    • Antisynthetase syndrome top comorbidities/symptoms
      Chart is omitted due to low report count.

      Antisynthetase syndrome top autoimmune comorbidities


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      * Disease is suspected as autoimmune, but unconfirmed.
      Data Source: Graphs on this page represent data from the Autoimmune Registry Inc. here. To protect participant anonymity, results derived from fewer than 5 participants are not graphed. The Autoimmune Registry Inc is a 501(c)(3) non-profit supported by donors like you.

    • Anti-inflammatory / specialty medications and supplements

      Antisynthetase syndrome top immunosuppressants / autoimmune therapies


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      * Biologic medications.
      Data Source: Graphs on this page represent data in electronic health records from the All of Us research database. As of July 2024, there are 451,000 sets of electronic health records collected from participants. A snapshot of the data can be found here. To protect participant anonymity, results derived from fewer than 20 participants are not graphed.
      The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.

    • Quick links: 
      Quick Links

      Patient-reported 7-day average pain
      Chart is omitted due to low report count.


      Patient-reported 7-day average fatigue
      Chart is omitted due to low report count.


      General physical health
      Chart is omitted due to low report count.


      General mental health
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      Social and relationship satisfaction
      Chart is omitted due to low report count.


      General quality of life
      Chart is omitted due to low report count.


      Ability to carry out social roles and activities
      Chart is omitted due to low report count.


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      Data Source: Graphs on this page represent data in self-reported survey results from the All of Us research database. As of July 2024, there are 560,000 participants who have completed these surveys. This dataset, however, may not be representative of the US population. A snapshot of the data can be found here. To protect participant anonymity, results derived from fewer than 20 participants are not graphed.
      The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.

    • Quick links: 
      Quick Links

      Concerns about ability to pay
      Chart is omitted due to low report count.


      Feeling unheard by healthcare providers
      Chart is omitted due to low report count.


      Patient employment status
      Chart is omitted due to low report count.


      Patient insurance coverage
      Chart is omitted due to low report count.


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      Graphs for this disease are generated based on data from the Autoimmune Registry Inc.