The Autoimmune Registry
Juvenile Rheumatoid Arthritis Graphs for this disease are generated based on data from the All of Us database.
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  • Names
    • Juvenile Rheumatoid Arthritis
    • Juvenile arthritis
    • Juvenile Chronic Arthritis
    • Juvenile idiopathic arthritis
    • Pediatric rheumatic disease
    Abbreviations: JIA, JRA
    Category: Musculoskeletal
    Prevalence From 28,934 to 37,148 cases in the US (Harrold 2017). Female/Male ratio: 3.7x.
    Age of Onset Onset typically before 16 years old.
    Description Juvenile rheumatoid arthritis is a pediatric disorder affecting the joints. Damage occurs when immune cells penetrate the lining of the joints, causing inflammation. Patients typically experience joint pain and swelling, which may occur in a flare/remission pattern. Some subtypes have strong evidence of being autoimmune. The condition is diagnosed through exclusion, when joint inflammation lasts more than 6 weeks in a patient 16 years-old or younger and cannot be positively diagnosed with another condition.

    There are 7 types of juvenile arthritis:

  • 1. Systemic juvenile idiopathic arthritis occurs in at least one joint accompanied by fever for 2 weeks or longer. Other possible symptoms include rash or enlargement of the lymph nodes, liver, or spleen.

  • 2. Oligoarticular juvenile arthritis (oligoarthritis) occurs in not more than 4 joints in the 6 months following disease onset. After this point, the condition may remain stable (persistent oligoarthritis), or it may spread to additional joints (extended oligoarthritis). The eyes may also be affected.

  • 3. Rheumatoid factor positive polyarticular juvenile idiopathic arthritis (polyarthritis and rheumatoid factor positive are alternative terms) has symptoms similar to adult rheumatoid arthritis but occurs in children. Patients typically experience arthritis in a minimum of 5 joints in the 6 months following disease onset. Blood tests reveal the presence of rheumatoid factors, a type of autoimmune antibody. The evidence suggests strongly that this subtype is autoimmune.

  • 4. Rheumatoid factor negative polyarticular juvenile idiopathic arthritis (polyarthritis and rheumatoid factor negative are alternative terms) is marked by the same symptoms as patients with rheumatoid factor positive. The negative variety is distinguished from the positive variety by an absence of rheumatoid factors in the blood.

  • 5. Psoriatic juvenile idiopathic arthritis causes both arthritis and red skin rashes with white scaling (psoriasis). Irregularities in the fingers, nails, or eyes may also occur.

  • 6. Enthesitis-related juvenile idiopathic arthritis causes discomfort where the bone joins with other tissues, such as tendons and ligaments. Irritation is frequent in the hips, knees, and feet. Tissue besides the joints may also become inflamed.

  • 7. Undifferentiated arthritis describes patients whose symptoms are not compatible with the other 6 categories of juvenile arthritis, or whose presentation includes symptoms from multiple categories.

    • Some patients experience full relief from symptoms with medical attention, while others experience relapses throughout life. Treatments are available to control symptoms and improve function.

    Evidence of autoimmunity: Antibody
    ICD-10 Code: M08.0     SNOMED Code: 410795001
    Patient Groups
    Bloggers
    Symptoms
    Resources Link to Clinical Trials
    Link to PubMed
    References Link to Mayo Clinic
    Link to Cleveland Clinic
    Link to Healthline
    Profile by: Emily Romanello
  • Profile updated September 2024
  • Charts generated Nov 16, 2024 at 09:55 AM ET
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    Juvenile Rheumatoid Arthritis sex breakdown


    Juvenile Rheumatoid Arthritis age breakdown


    Patient ethnicities

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    Data Source: Graphs on this page represent data in electronic health records and self-reported survey results from the All of Us research database. As of July 2024, there are 451,000 sets of electronic health records and over 560,000 participants who have completed initial survey questions. This dataset, however, may not be representative of the US population. A snapshot of the data can be found here. To protect participant anonymity, results derived from fewer than 20 participants are not graphed.
    The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.

  • Juvenile Rheumatoid Arthritis top comorbidities/symptoms

    Juvenile Rheumatoid Arthritis top autoimmune comorbidities


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    * Disease is suspected as autoimmune, but unconfirmed.
    Data Source: Graphs on this page represent data in electronic health records from the All of Us research database. As of July 2024, there are 451,000 sets of electronic health records collected from participants. In the United States, because electronic health records use billing codes for diagnoses, some conditions may not be perfectly captured by these data, especially if the condition is rare. A snapshot of the data can be found here. To protect participant anonymity, results derived from fewer than 20 participants are not graphed.
    The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.

  • Anti-inflammatory / specialty medications and supplements

    Juvenile Rheumatoid Arthritis top immunosuppressants / autoimmune therapies


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    * Biologic medications.
    Data Source: Graphs on this page represent data in electronic health records from the All of Us research database. As of July 2024, there are 451,000 sets of electronic health records collected from participants. A snapshot of the data can be found here. To protect participant anonymity, results derived from fewer than 20 participants are not graphed.
    The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.

  • Quick Links
    Patient-reported 7-day average pain Patient-reported 7-day average fatigue General physical health General mental health Social and relationship satisfaction General quality of life Ability to carry out social roles and activities

    Patient-reported 7-day average pain


    Patient-reported 7-day average fatigue


    General physical health


    General mental health


    Social and relationship satisfaction


    General quality of life


    Ability to carry out social roles and activities


    Join the registry!

    Data Source: Graphs on this page represent data in self-reported survey results from the All of Us research database. As of July 2024, there are 560,000 participants who have completed these surveys. This dataset, however, may not be representative of the US population. A snapshot of the data can be found here. To protect participant anonymity, results derived from fewer than 20 participants are not graphed.
    The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.

  • Quick Links
    Concerns about ability to pay Feeling unheard by healthcare providers Patient employment status Patient insurance coverage

    Concerns about ability to pay


    Feeling unheard by healthcare providers


    Patient employment status


    Patient insurance coverage


    Join the registry!

    Data Source: Graphs on this page represent data in electronic health records and self-reported survey results from the All of Us research database. As of July 2024, there are 451,000 sets of electronic health records and over 560,000 participants who have completed initial survey questions. This dataset, however, may not be representative of the US population. A snapshot of the data can be found here. To protect participant anonymity, results derived from fewer than 20 participants are not graphed.
    The All of Us Research Program is supported by the National Institutes of Health, Office of the Director: Regional Medical Centers: 1 OT2 OD026549; 1 OT2 OD026554; 1 OT2 OD026557; 1 OT2 OD026556; 1 OT2 OD026550; 1 OT2 OD 026552; 1 OT2 OD026553; 1 OT2 OD026548; 1 OT2 OD026551; 1 OT2 OD026555; IAA #: AOD 16037; Federally Qualified Health Centers: HHSN 263201600085U; Data and Research Center: 5 U2C OD023196; Biobank: 1 U24 OD023121; The Participant Center: U24 OD023176; Participant Technology Systems Center: 1 U24 OD023163; Communications and Engagement: 3 OT2 OD023205; 3 OT2 OD023206; and Community Partners: 1 OT2 OD025277; 3 OT2 OD025315; 1 OT2 OD025337; 1 OT2 OD025276. In addition, the All of Us Research Program would not be possible without the partnership of its participants.